Development of Innovative Treatment Technologies in Korean Medicine

New brain transmission and outflow pathways

Instead of the existing blood-brain barrier (BBB) Deep cervical lymph nodes and olfactory plexus pathwaysUtilizes.

• · Exploration of cerebral drug delivery via deep cervical L-PVS and efflux of toxic proteins (P-tau, Aβ, A-synuclein) via deep cervical lymphatic vessels
• · Exploration of anti-inflammatory and neuroprotective effects following administration of a novel Pdop liquid formulation via olfactory plexus pathways

Development of advanced technology for nano-sized, water-soluble liquid-based Pdop solvent coatings

After manufacturing a sulfur-free liquid hydroxide and completely removing heavy metals, we developed a sulfur nanomaterial by sulfur-coating it with Pdop solvent. We evaluate the therapeutic potential of this liquid hydroxide for neurodegenerative diseases (AD, PD) through animal experiments utilizing the deep cervical L-PVS and olfactory plexus.

Sulfur-based research in the pathology of degenerative brain diseases

H in Alzheimer's disease₂Based on domestic and international research on S-based neuroprotective mechanisms and sulfur-transfer channel-based neuromodulation failure in Parkinson's disease, we elucidate the neuroprotective effects of sulfur ions.

Research results

The Alzheimer's disease model exhibited a common pattern of increased mast cell density and degranulation in organ surface and meningeal PVS, and an increase in the diameter and density of Primo pores and a decrease in the diameter of fibrous structures were observed.